PhD Students at Erasmus MC

The aim of the project "SYMPHONY: Orchestrating personalized treatment for patients with bleeding disorders" is to establish best treatment choice for each individual with a bleeding disorder based on bleeding tendency. This will be achieved by improving current diagnostic tests to measure hemostatic potential and by performing fundamental research into the pathophysiology behind interindividual differences in bleeding phenotype and treatment response, using novel techniques such as proteomics, and both IPSc and endothelial cellular systems.

This will be achieved by intensive collaborations between the twelve workpackages (WP) (14 fte PhD and 1 fte postdoc), divided into three themes: Diagnostics, Treatment and Fundamental research. Clinical research will focus on a.o.:
Treatment optimization by personalization, increasing quality of care at acceptable costs;
Guidance of complex clinical shared decision making for novel therapeutic options;
Patient-orchestrated implementation of health care innovations using e-health modules.
The SYMPHONY consortium is a broad interdisciplinary cooperation consisting of diverse disciplines: (Pediatric) Hematology, Vascular Medicine, Clinical Genetics, Clinical Pharmacology, Psychology, Ethics, Epidemiology & Methodology, Mathematics, Health Care Economics, Information & Data Technology, Biochemistry, Molecular Biology, Molecular Genetics and Cell Biology, Laboratory Medicine, Business Economics, Marketing, Sales & Patient Advocacy.

For this project a total of 14 PhD's will be hired, these are the vacancies within the Erasmus MC:
WP03 - Novel diagnostic assays for coagulation factor deficiencies
WP05 - Establishing a value-based health care approach
WP06 - Dose individualization of factor concentrates and desmopressin using population pharmacokinetic (PK) modelling
WP08 - Costs and effects of personalized treatment in bleeding disorder patients

Further details:
PhD Students at Erasmus MC