The goal of the project is to use gene regulatory network inference to discover new regulatory mechanisms that control the repertoire of RBPs. To this end, software will be adapted and developed in order to infer reliable GRNs and to analyse results. Both in-house and public shRNA-RNAseq data from ENCODE will be used. Inferred GRNs will be analysed for regulatory links in relation to known functions and RNA binding and are subjected to experimental validation of the scientifically most valuable links.
The project involves programming, data analysis, benchmarking, and modelling, as well as application of the developed methods to experimental data.
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2 Postdoctoral Researchers in bioinformatics at Karolinska Institute