For the first time, it is now realistic to follow individual patients in full clinical and molecular detail over the course of diagnosis, first-line treatment and recovery, cure and/or relapse. Prospectively studying representative patients for several cancers, we will combine (i) Omics Profiling including Single-Cell Epigenome/Transcriptome Sequencing, (ii) Patient-specific 3D Culture Models, (iii) Multimodal Imaging, (iv) Digital Pathology and (v) Clinical Phenotyping, in order to establish systems medicine accounts of individual patients. At this level of detail, each patient becomes a powerful study in itself, providing novel insights into complex disease mechanisms and informing personalized therapy.
The Candidate
We are looking for highly motivated and academically outstanding candidates who want to pursue a scientific career in the field of computational and medical epigenomics. A strong candidate may have a background in the computational sciences (bioinformatics, statistics, physics, engineering, etc.) and some prior experience with collaborative research in high-throughput biology. In the same way, we are considering applicants with a background in medicine or in biology (e.g., functional genomics, chemical biology, human genetics, molecular medicine, etc.) who have strong quantitative skills and a keen interest in pursuing systems medicine projects.
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