Fifteen (15) PhD Positions in Synaptic Dysfunction in Alzheimer Disease, Karolinska Institutet, Europe (2016)

SyDAD is an interdisciplinary PhD programme including an innovative research programme with cutting edge methodology, an excellent training programme, international exchanges and a translational and collaborative orientation.
Aims:

- To foster a new generation of researchers with an innovative mind-set and full understanding of the requirements of academia, pharmaceutical companies, the clinics and the societal challenges.
- To, through a collaborative research programme, elucidate how the different pathways underlying synaptic dysfunction in Alzheimer Disease (AD) relate to each other, to identify novel pharmaceutical targets and to elaborate a drug discovery platform.

The doctoral education projects and the duties of the student
The doctoral students will use biochemical, cell biological, electrophysiological and in vivo methods as well as clinical material. The network has access to a wide repertoire of cutting-edge methodology including super-resolution microscopy, mass spectrometry, in vivo electrophysiology and optogenetics. The doctoral students will be seconded to other sites of the network during shorter periods to best utilize the resources of the network and participate in a common training programme at the different sites of the network.

The applicants are asked to send separate applications directly to each organisation and to provide a list of which SyDAD projects (maximum three) they have applied for.

Karolinska Institutet, Stockholm, Sweden:
- ESR 10: Targeting Cholesterol homeostasis and synaptic maturation.
Contact: angel.cedazo-minguez@ki.se
- ESR 11: Synaptic proteome and Aβ interactome in AD brain and mouse models.
Contact: susanne.frykman@ki.se
- ESR 13: EEG as a functional central biomarker in AD.
Contact: vesna.jelic@ki.se
- ESR 14: Mitochondria stabilisers and synaptic function in AD.
Contact: maria.ankarcrona@ki.se

Apply to the projects at Karolinska Institutet at http://ki.se/en/about/jobs-at-karolinska-institutet

University of Bordeaux, France:
- ESR 2: Role of APP in presynaptic mechanisms.
Contact: gael.barthet@u-bordeaux.fr
- ESR 7: Mitochondrial dysfunction in relation to synaptic function in mouse models of Alzheimer’s disease.
Contact: Sandrine Pouvreau sandrine.pouvreau@u-bordeaux.fr
- ESR 12: Plasticity of local hippocampal circuits in mouse models of Alzheimer’s disease: relation with episodic memory encoding.
Contact: christophe.mulle@u-bordeaux.fr

Apply to the projects at University of Bordeaux by e-mail: christophe.mulle@u-bordeaux.fr

University of Milano, Italy:
- ESR 1: Linking actin-dependent dendritic spine remodelling and ADAM10 activity in AD: the role of CAP2.
Contact: monica.diluca@unimi.it
- ESR 9: A spine to nucleus signalling pathway in Alzheimer’s disease.
Contact: fabrizio.gardoni@unimi.it
- ESR 15: Development of cell permeable peptides capable of increasing ADAM10 activity. Contact: monica.diluca@unimi.it

Apply to the projects at University of Milano by e-mail: monica.diluca@unimi.it and fabrizio.gardoni@unimi.it

Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany
- ESR 3: Cascade linking Aß and tau-dependent toxicity to synapse loss.
Contact: Mandelkow@dzne.de
- ESR 4: Loss-of-function genetic screening using CRISPR/Cas9.
Contact: Daniele.Bano@dzne.de
- ESR 8: Synaptic plasticity and calcium remodelling.
Contact: office-nicotera@dzne.de

Apply to the projects at DZNE by e-mail: application@dzne.de

Janssen Pharmaceutica NV, Beerse, Belgium
- ESR 6: The roles of physiological and pathophysiological tau in synapse function and morphology.
Contact: jpitaalm@ITS.JNJ.com

Apply for the project at Janssen here: http://jobs.jnj.com/s/u3z0MT

Axon Neuroscience, Bratislava, Slovakia
- ESR 5: Rescue of truncated Tau-mediated synaptic dysfunction in vivo. Contact: novak@axon-neuroscience.eu

Apply to the projects at Axon by e-mail novak@axon-neuroscience.eu

Further details:
http://academicpositions.eu