Cell competition, a cell fitness sensing mechanism by which abnormal cells are eliminated during animal development, is receiving increasing attention because of its possible roles in the prevention and early development of cancer. The molecular mechanisms of cell competition and its physiological significance are still emerging. Cell competition may also be useful in regenerative medicine.
Postdoctoral positions are available in the laboratories of Dr. Nicholas Baker and Cristina Montagna to study the mechanisms and physiological functions of cell competition using either Drosophila or mice, exploiting newly-derived mouse and Drosophila mutants. Elimination of unfit cells will be studied at the molecular level. This will include Aneuploid cells, ie cells with gain or loss of chromosomes, which contribute to birth defects, cancer and aging if not eliminated. Our research is interdisciplinary and involves molecular genetics, cell biology and biochemistry studies. The successful applicant will have a PhD in a relevant discipline, ambitious scientific interests and the drive to succeed in scientific research. Experience in molecular biology or in Drosophila or mouse developmental genetics may be an advantage.
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Postdoctoral Positions studying Cell Competition in flies or mice at Albert Einstein College of Medicine