Cells need to carefully control their internal stores of inorganic phosphate, which is both an essential nutrient and potentially toxic. They face a phosphate challenge for several reasons. Growth requires a minimal concentration of this limiting resource because intracellular inorganic phosphate (Pi) is a compound of nucleic acids and modifies most cellular proteins. At the same time, cytosolic Pi may not rise much, because elevated cytosolic Pi can stall metabolism. It reduces the free energy that nucleotide triphosphate hydrolysis can provide to drive energetically unfavorable reactions.
University of Lausanne is seeking highly motivated collaborators to characterize this fundamental, novel signaling and homeostasis pathway in the framework of a project funded by the European Research Counci for 5 yearsl. Candidates with training in biochemistry, chemistry, molecular or cell biology, and plant biology, are particularly encouraged to apply. Knowledge of yeast genetics is advantageous but not essential.
Further details:
Postdoctoral and PhD Positions in Nutrient Signaling at University of Lausanne