The focus areas of these research projects are on the development of surface-based bioanalytical instrumentation and/or their use in fundamental biophysics research as well as for applications in medical diagnostics and drug discovery. With respect to method development, surface-sensitive optical microscopy will be further developed together with advanced lipid-based surface modifications and microfluidics to enable single-molecule studies of the biomolecular interactions that forms the foundation for many diagnostic applications. The project will also include work on new means to make protein structure determinations at the level of single molecules. From the perspective of applications, the work will be carried out in close collaboration with biological and medical settings, with particular focus on how single nanoparticle analytics can offer advantages with respect to faster and more informed medical diagnostic devices, improvements in the discovery of drugs directed against membrane proteins as well as nanoparticle formulations of next generation biological drug compounds. Prime emphasis will be put on fundamental science, but the applied nature of the work means that it will also be carried out in close connections with the utilization network at Chalmers.
Major responsibilities
The successful candidates will work on these research topics in a relatively large research team, with participants from many departments at Chalmers and national and international universities. The main responsibility for one of the candidates will be the further development of advanced instrumentations, including advanced analysis. The other candidate will be responsible for applications of state-of-the art single-molecule analysis in diagnostic and drug-discovery applications. The candidates may also participate in experiments at large international infrastructure facilities.
Further details:
Postdoctoral positions in biological physics at Chalmers University of Technology