Ζωής

FLOW aims to uncover the molecular principles of how the cellular protein quality-control network modulates the fate of proteins from cradle to grave. Molecular chaperones and the degradation machinery determine the fate of proteins, and failure to do so leads to diseases as divergent as neurodegeneration or cystic fibrosis. The FLOW consortium, a unique and highly interdisciplinary team, aims to discover, rebuild and control the triaging of protein fate. We do this by combining biochemical, biophysical, cell biological, computational, and genetic methods, from single molecule to cell.