Διδακτορικό

In the last ten years, Fragment-Based Lead Discovery FBLD (also known as Fragment-Based Drug Discovery FBDD) has proven to be an effective approach towards the discovery of small molecule compounds (ligands) that can bind to biological target molecules. The key feature of this approach is that ligand discovery begins with the screening of low molecular weight compounds (“fragments”) that have a higher chance of binding to a target in comparison to whole (drug) candidate molecules.