Bone defects constitute a major health burden. Current therapies are insufficient, in particular for large defects or if the self-healing capacity is compromised. This is why novel therapies are urgently required. Two PhD positions are currently available at Radboudumc within the framework of the project "RNA4Bone" to develop novel colloidal biomaterials, self-assembled from nanoparticles containing mRNA coding for growth factors to stimulate bone regeneration.