Ιατρική

PhD positions
Enzyme catalysis at the polymer surface
Glycogen is a glucose-based polymer, comprising linear and branched components in a tree-like arrangement. Hence, an enzyme acting upon glycogen can cleave or rearrange the polymer backbone at multiple sites. The challenge will be to develop novel experimental and computational tools that can resolve spatiotemporal aspects of enzyme catalysis at the complex polymer surface, and apply these to clinical samples and data to identify bottlenecks and therapeutic targets.