The 5 PhD students with backgrounds in (bio)physics, (bio)chemistry, systems-, computational- or molecular biology will conduct curiosity-driven biomolecular research to investigate a bold hypothesis, which has potential to radically change our view on the inner working of a cell. The research will be performed in one of five different research groups of the Groningen Biomolecular Sciences and Biotechnology Institute. There will be significant interactions and collaborations between the five PhD students and all of the involved research groups.