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The Haigh lab uses cutting edge transgenic mouse models and ES/iPS cell-based technologies to better understand cell fate and cellular transformation at the molecular level. Here the role of the ZEB and SNAI family of transcription factors in normal haematopoietic stem cell differentiation and lineage commitment (see Goossens et al., Blood, 2011) as well as their roles in the development of leukemic cancer stem cells with a focus on T-Cell Acute Lymphoblastic Leukemia (T-ALL) will be further investigated (See Goossens et al., Nature Communications, 2015).