For the first time, it is now realistic to follow individual patients in full clinical and molecular detail over the course of diagnosis, first-line treatment and recovery, cure and/or relapse. Prospectively studying representative patients for several cancers, we will combine (i) Omics Profiling including Single-Cell Epigenome/Transcriptome Sequencing, (ii) Patient-specific 3D Culture Models, (iii) Multimodal Imaging, (iv) Digital Pathology and (v) Clinical Phenotyping, in order to establish systems medicine accounts of individual patients.