University of Utrecht is looking for highly self-motivated Msc students with a degree in Medicine or Biomedical Sciences who are looking for an ambitious PhD project. The PhD students will be involved in relatively small-scale human intervention trials, in which she/he will perform a thorough characterization of 24h muscle metabolism and insulin sensitivity after timed food intake and timed exercise (training). For this, we will make use of techniques such as indirect calorimetry, hyperinsulinemic-euglycemic clamps and magnetic resonance spectroscopy. In addition, we will take muscle biopsies to allow for more in-depth molecular analyses. A strong (international) research group and -network is available to aid in the execution of the project and to receive additional training. Due to its 'round-the-clock' nature, the project is not compatible with a 9-to-5 mentality and candidates should be willing to work outside regular office hours.