The research group has performed single-cell/spatial omics studies, identifying for instance several cell states within the oligodendrocyte lineage in development and disease (Science 2016, Dev Cell 2018, 2022, Nature Medicine 2018, Nature 2019, 2023 Nature Biotechnology 2021, 2022, Neuron 2022, Cell 2024,among others). The recent findings suggest that oligodendrocyte lineage cells might present other functional properties than previously thought, transitioning for instance to disease-associated states. The PhD student projects will focus on the development and/or computational analysis of spatial transcriptomic and epigenomic technologies, and application to multiple sclerosis. The successful candidate(s) will be integrated in a multidisciplinary team comprising computational, molecular and cellular biologists and neuroimmunologists.