The semiconductor industry is vital to global economic growth and technological progress, powering everything from energy solutions to healthcare innovations. Some parts of the design of these high-tech systems - lithography machines – can be automated. However, current design automation solutions are limited to specific domains or subsystems. Holistic system-level design is a necessary next-step because of the complexity of these systems. This implies going beyond current domain-specific solutions by combining mechanical, electrical, software, data science, and AI-expertise.