The research activities implemented in the 4 scientific Work Packages of GLYCOVAX will be applied to epidemiologically relevant disease areas of meningitis, neonatal infections, and nosocomial infections. The fourteen ESR’ projects have been defined in:
- ESR 1: Synthesis of oligosaccharide libraries from Group B streptococcal capsular polysaccharide for structure-based selection of vaccine candidates (GSK Vaccines, Siena, ITALY) OPEN
- ESR 2: Synthesis of Group B Streptococcus type V oligosaccharides for vaccine development (University of Milan, Milan, ITALY) OPEN
- ESR 3: Synthesis of MenA carba-analogues and native MenX oligomers for improved anti meningococcal vaccines (University of Milan, Milan, ITALY) OPEN
- ESR 4: Generation of libraries of carbohydrate containing Enterococcal antigens (University of Leiden, Leiden, THE NETHERLANDS) OPEN
- ESR 5: Automated synthesis of Lancefield group B carbohydrate fragments and their use in bivalent unimolecular glycoconjugate vaccines (University of Leiden, Leiden, THE NETHERLANDS) OPEN
- ESR 6: Synthesis of oligosaccharide antigens from Staphylococcus aures type 5 and 8 capsular polysaccharides (Max Planck Institute for Colloids and Interfaces, Potsdam, GERMANY) OPEN
- ESR 7: Automated synthesis of a library of Group B Streptococcus type IV capsular polysaccharide related glycans for vaccine development (Glycouniverse, Berlin, GERMANY) NOT OPEN YET
- ESR 8: Chemo-enzymatic strategies for the synthesis of sialylated oligosaccharides (University of Manchester, Manchester, UNITED KINGDOM) CLOSED
- ESR 9: Development and application of polysaccharide-specific monoclonal antibodies (Medicine Faculty of the University of Rijeka, Rijeka, CROATIA) OPEN
- ESR 10: Structural characterization of the interactions between meningococcal and Group B streptococcal carbohydrate antigens and monoclonal antibodies (GSK Vaccines, Siena, ITALY) OPEN
- ESR 11: Minimal structural glyco-epitope for antibody maturation (National Centre of Scientific Research, Villeneuve d’Ascq, FRANCE) OPEN
- ESR 12: NMR studies of the interactions of glycan antigens with monoclonal antibodies (Center for Cooperative Research in Biosciences, Derio Vizcaya, SPAIN) OPEN
- ESR 13: A modular approach to the construction of glycoprotein vaccine candidates uniform in site and glycan loading number (Institute of Molecular Medicine, Lisbon, PORTUGAL) OPEN
- ESR 14: Identification of immunoreactive synthetic compounds (University of Munich, Munich, GERMANY) OPEN
Each of the 14 ESRs will be enrolled in the PhD programme of the beneficiary’s organization (the beneficiaries which do not award PhD will establish agreements with local and international universities that can provide the degree) and will participate in the network’s training activities and work placements at the laboratories of the participating academic and industrial partners. In addition, the training programme of the recruited ESRs will be supplemented by regular meetings and workshops within the GLYCOVAX International Training Network.
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