Three (3) Postdoctoral Positions in DNA Damage in Cancer, BioMed X Innovation Center, Germany (2016)

Applications are welcome from early career scientists with an outstanding track record in the field of: DNA Damage in Cancer

Merck is seeking to identify novel approaches to exploit cellular DNA damage and repair mechanisms which occur during radiation and radiochemotherapy in order to increase therapeutic efficacy and reduce side effects of such treatments.

Desired skills and experience

Applicants should focus their project proposals on the following objectives:
- Evaluation of radio(chemo)therapy in preclinical model systems using genetic and pharmacological approaches, ideally including preclinical in vivo studies
- Analysis of molecular determinants of sensitivity/resistance to radiotherapy
- Identification and evaluation of DNA damage/repair-related vulnerabilities in cancer (synthetic lethality concepts)

Experimental approaches should include pre-clinical in-vitro and in-vivo model systems to study the molecular mechanisms which determine cellular sensitivity or resistance to radiotherapy. An integral part of the investigations should be the characterization of Merck’s proprietary compounds inhibiting DNA repair pathways. Proposals building on very original ideas supported by first experimental findings are particularly encouraged.

Candidates for postdoctoral positions are expected to have several years of research experience and a certain degree of specialization in one or more relevant cutting-edge technologies.

Further details:
http://www.researchgate.net