Eleven (11) PhD Positions in antibacterial drug discovery, University of Helsinki, Finland (2015)

Applications are invited for 11 PhD student positions (“Early Stage Researchers”) to be funded by the Marie-Sklodowska-Curie Innovative Training Network “INTEGRATE – Interdisciplinary Training Network for Validation of Gram-Negative Antibacterial Targets” within the Horizon 2020 Programme of the European Commission.

The 11 available positions:

ESR 1. Design, synthesis and optimization of inhibitors of enzymes involved in the sulfur assimilation pathway in Gram-negative bacteria

ESR 2. Characterization of S. typhimurium sulfur assimilation targets SAT and OASS

ESR 3. Systematic bioactivity evaluation of potential antibacterial agents in vitro: From biosensor-based HTS to follow-up studies

ESR 4. Computer-aided drug design, hit finding and optimization

ESR 5. Design and synthesis of mechanism based O-acetylserine sulfhydrylase inhibitors

ESR 6. The glyoxylate shunt as a target for antibacterial intervention in Gram-negative bacteria

ESR 7. Discovery of novel gyrase B and gyrase B/topoisomerase IV (ParE) dual inhibitors with in vitro antibacterial activity

ESR 8. E. coli LsrK Kinase Inhibitors as Quorum Sensing interfering agents: validation of therapeutic potential

ESR 9. Identification of novel covalent ClpP inhibitors as inhibitors of gram-negative bacteria

ESR 10. Design, synthesis and characterization of novel modulators of ClpP proteases from Gram-negative bacteria

ESR 11. In vitro characterization and in vivo efficacy evaluation of selected compounds against relevant biofilm-producing Gram-positive and Gram-negative pathogens

Further details:
http://ec.europa.eu