3 PhD Positions, Utrecht University, Netherlands (2017)

We seek to fill 4 years (1.0 FTE) or 5 years (0.8 FTE) PhD positions on image processing of cryo-electron tomography images. The positions are available immediately in joint projects of the groups of Prof. Friedrich Förster (Department of Chemistry) and Prof. Remco Veltkamp (Department of Information and Computing Sciences) at Utrecht University.

In a joint project, the PhD candidate will develop novel methods for detection of macromolecular complexes in low signal-to-noise ratio volumes using machine-based learning (e.g., ‘deep learning’). The main research question is how to improve the successive stages in cryo-electron tomography: detection, alignment, and classification.

The research in the cryo-EM group headed by Prof. Förster focuses on structural studies of membrane-associated processes in their native settings. In essence, the aim is to observe molecules at work in cells using cryo-electron tomography (cryo-ET) in conjunction with advanced image analysis. To this end the group develops and applies computational methods for three-dimensional tomographic reconstruction and statistical analysis to mine the volumetric data. The research in the group of Prof. Veltkamp centers on developing efficient methods for aligning, reconstruction, and recognition of shapes, which will be combined and improved further. The challenge is to research novel 3D macromolecular complex features, similarity measures, and classification technologies, and to evaluate these with scientific rigor.

The task of the PhD candidate is to perform research on the above topics, develop novel algorithms, perform sound experiments, publish the results at international conferences and in scientific journals, complete a PhD thesis, and guide student projects.

Requirements
The successful PhD candidate is an excellent student and holds a Master degree in Computational Sciences, Mathematics, (Bio) Physics, or a related field of science. Previous experience in signal and image processing would be a plus. Strong written and oral communication skills in English and interest in biological research are required.

Further details:
http://www.academictransfer.com