Two Postdoctoral Research Positions at Utrecht University

The Gros lab at the Bijvoet Centre for Biomolecular studies is currently seeking two post-doctoral researchers to strengthen our team. The Gros lab studies biomolecular recognition and regulation processes in the area of infection and immunity. The lab has an internationally strong reputation in uncovering the molecular mechanisms that underpin the complement system. We combine protein crystallography, cryo-electron microscopy, light microscopy, biochemical and biophysical assays to get a detailed picture of the molecular interactions that enable the complement system to discriminate between healthy self-cells and pathogens or dying/malignant cells. The goal of the current projects is to understand how the molecular mechanisms of complement attack and defence on cell membranes determines whether a cell is destined for clearance or not. These are challenging projects that involve several large, flexible, sometimes transient, protein complexes that work in tandem to achieve an adequate native immune response to invading microbes and altered-self, whilst avoiding bystander damage to host cells. The group offers a highly collaborative environment where candidates will have ample opportunity to continue developing their skills to further their careers.