Genome editing is revolutionising our ability to study gene function, as well as the treatment of diseases. Engineered nucleases, able to efficiently target defined DNA loci, are key reagents in genome editing. The objective of this project is to develop strategies to alter and retune the activity of genome editing enzymes such as CRISPR-Cas, by mechanistic and structural analysis and also directed evolution.
Please see website for further details on the project and available funding
Research Fields
Chemistry
Eligibility criteria
Applicants should have a first or upper second class degree in biochemistry, biotechnology, chemistry or a related, relevant subject. Specific skills in any of the following areas is an advantage: protein engineering, analysis of enzyme mechanism, directed evolution, cloning, DNA manipulation (including preparation and handling of DNA libraries), familiarity with molecular (e.g. phage or ribosome display) or mammalian cell culture techniques.
Further details:
http://ec.europa.eu