Postdoctoral Researchers in B cell development and relevant diseases

The selected two top postdoctoral candidates will work on a Knut and Alice Wallenberg Foundation funded project entitled “Developmental trajectories for human B cells” and will be supervised by Dr. Qiang Pan-Hammarström at Karolinska Institutet (KI). The project will be conducted in close collaboration with three additional research groups led by Drs. Petter Brodin, Lennart Hammarström and Hong Qian respectively.

The main tasks for the successful candidates are:

1) Characterization of B-cell subsets from primary and secondary lymphoid tissues from normal individuals using unbiased single-cell approaches.

2) Identify regulatory modules that drive B-cell differentiation and to model this process in vitro by using inducible pluripotent stem cells and CRISPR-based screening.

3) Identification of developmental or regulatory defects in B cell related disorders such as primary immunodeficiency, B cell malignancies, autoimmune disorders, allergy and infectious diseases such as COVID-19.