Significantly, the genetic material of many viruses, including influenza, HIV and SARS-CoV-2, consist of RNA folded into complex 3D structures. Single-molecule techniques have revolutionized the understanding of complex NA structures and their interactions with therapeutic oligonucleotides, small molecules, and proteins. However, for Europe to adapt to new therapeutic challenges and to increase its competitiveness, new expertise is urgently required in single-molecule analysis of NAs, a research field that intersects physical chemistry, biophysics, chemical synthesis, and molecular simulation.
At the University of Amsterdam, dr. Jocelyne Vreede from the van ‘t Hoff Institute for Molecular Sciences is involved in this Doctoral Network and has vacancies for two doctoral candidate positions in molecular simulation of nucleic acids.
What you will do
You will construct molecular models of nucleic acids;
You will relate nucleic acid models to single molecule experiments;
You will work in close collaboration with nucleic acids experts research in the Marie Skłodowska Curie Doctoral Network MeChaNiSM;
In the network, you participate in innovative training modules, including a series of hands-on workshops that provide technical, transferable and presentation skills, international conferences, and outreach activities.