Postdoctoral Positions, Karolinska Institutet, Sweden (2017)

Post doc positions in Tumor and Cell Biology: Oxygen Sensing and Cancer Group : Stockholm, Sweden

Karolinska Institutet, Department of Microbiology, Tumor and Cell Biology: Oxygen Sensing and Cancer Group

The Schlisio lab at Karolinska Institute and Ludwig Institute, Sweden, seeks postdoctoral fellows, to work on molecular mechanisms of oxygen sensing and cancer.

Our research concerns the mechanisms of how disruption of oxygen-sensing pathways can lead to cancer. Oxygen sensors enable the cell to adapt to low-oxygen environments and are critical for normal development and apoptosis. These events are often disrupted in the development of tumors. Oxygen sensing is mediated partly via prolyl hydroxylases that require molecular oxygen for enzymatic activity. Our work focuses on how prolyl hydroxylases execute apoptosis in neural precursors during development and how disruption of this process can lead to certain forms of nervous-system tumors.

(1)
We are seeking a motivated, creative post-doctoral candidate interested in tumor mouse models arising from the sympatho-adrenal lineage, such as neuroblastoma and pheochromocytoma, with the aim to understand the molecular principles of these tumors at a previously unprecedented level.

(2)
Furthermore, we are looking for motivated, creative post-doctoral candidates interested in cancer metabolism with knowledge in basic biochemistry and molecular biology. We currently defining how oxygen sensing regulates mitochondrial dynamics and mass.

(3)
In addition, we are looking for one outstanding researcher to work on the computational analyses of a large-scale single-cell transcriptome project on neuroblastoma. In this project we will generate “molecular encyclopedias” of this tumor in order to understand the molecular principles concerning the origin, progression and subtypes of this tumor at a previously unprecedented level, using state-of-the-art RNA-seq and bioinformatics technologies. Therefore, we seek one postdoctoral research fellow with expertise in computational analyses of RNA-seq data and OMICS data.

Position-specific requirements: The postdoctoral fellow in computational analyses of single-cell RNA-seq data should have a strong background in genome-wide bioinformatics, programming and linux environment. Previous experience with RNA-seq data analyses is required and additional experience with single-cell data, post-transcriptional gene regulation (e.g. splicing) or machine learning is a strong merit.

General requirements:
A person is eligible for a position as postdoctoral research fellow if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc. Successful applicants must have the ability to work both independently and collaboratively in a group and have good English communication skills.
Location: Dept MTC, Karolinska Institutet.

Further details:
http://www.researchgate.net