The Antebi Department for “Molecular Genetics of Ageing” investigates how regulatory networks govern animal health and life span. We primarily use the roundworm Caenorhabditis elegans and the turquoise killifish Nothobranchius furzeri as model organisms, as well as cell culture and mouse. The overarching goals are to reveal conserved, convergent mechanisms of longevity, and to understand how immunity, metabolism, and quality control mechanisms cooperate in cellular defense. We apply a multidisciplinary approach combining genetics, systems biology, cell and molecular biology, imaging, biochemistry and mass spectrometry in order to understand the biology of ageing and age-related disease. In particular, we have a long-standing interest in understanding how naturally occurring metabolites can serve as signalling molecules that regulate animal health and life span, and are using metabolomic approaches to identify such factors.