2 Postdoctoral Researchers in structural and biophysical studies of the complement system at Utrecht University

The Gros lab at the Bijvoet Centre for Biomolecular Research, Utrecht University is currently seeking two post-doctoral researchers for an ERC funded project on biophysical and structural aspects of the human complement system. The Gros lab studies biomolecular recognition and regulation processes in the area of infection and immunity. The lab has an internationally strong reputation in uncovering the molecular mechanisms that underpin the complement system. We combine protein crystallography, cryo-electron microscopy, light microscopy, biochemical and biophysical assays to get a detailed picture of the molecular interactions that enable the complement system to discriminate between pathogens or dying/malignant cells and healthy self-cells. The goal of the current projects is to understand how the molecular mechanisms of complement attack and defence on cell membranes, which determines whether a cell is destined for clearance or not. In particular we will address the role of membrane organisation and dynamics in the equilibrium between complement attack and defence.

Key research questions are:
How are membrane proteins organised?
How does signalling depend on membrane-protein organization?
How does complement respond to membrane organization?

Further details:
2 Postdoctoral Researchers in structural and biophysical studies of the complement system at Utrecht University